"Jack" JBS Haldane

Compiled via the efforts and contributions of Many....

Transcribed and presented to the web....


By Colleen Cahoon, of Texas


Introduction: I found the following via the outstanding internet resource, Wikipedia.   There was enough material on the following family to encourage me to simply establish a link to the data.   That would have been easier, but I am familar enough with the resource and others on line, as well, to know that what is available to access today, may not be so on the morrow.  So for the entertainment of my living relatives and my descendants, I am providing the articles herewithin.  I almost titled these pages, "Royalty, Mariners, Preachers and Aethists" or "Science, the X-factor" or "Education teaches that it is okay to change your mind" but as you may have noticed, I simply refer to it as "Jack" JBS Haldane... aka... the man who coined the word, "clone", and who happened to have been an aethist and Great Grandson of an Evangalical Preacher James Alexander Haldane as well as son of the man who invented the gas mask, John Scott Haldane and brother to a prolific writer, Naomi Haldane Mitchison who helped proof-read her friend's epic novel, Lord of the Rings.



[Jack (JBS) Haldane's Family Tree]

John Burdon Sanderson Haldane (November 5, 1892 - December 1, 1964) was born in Edinburgh, Scotland, to physiologist John Scott Haldane and Louisa Kathleen Haldane (née Trotter), and descended from Scottish aristocrats (see Haldane family ).    His younger sister Naomi Mitchison became a writer.   His uncle was Richard Haldane, 1st Viscount Haldane , politician and one time Secretary of State for War and his aunt was the author Elizabeth Haldane .

Known as "Jack," JBS Haldane was educated at Dragon School , then at Eton (where he spent six years and suffered a certain amount of bullying at first, but ended up being Captain of the School) and at New College, Oxford , where he graduated in 1911.

In January 1915, JBS Haldane entered the First World War in France, serving with the Black Watch in France and Iraq .   He was initially Bombing Officer for the 3rd Battalion before becoming a Trench Mortar Officer in the 1st.   He took to the task of Bombing Officer with such enthusiasm that he was nicknamed Bombo.   While in the army, he became a socialist , writing "If I live to see an England in which socialism has made the occupation of a grocer as honourable as that of a soldier, I shall die happy".   He completed his war service in January 1919.

Between 1919 and 1922 JBS was a Fellow of New College, Oxford , then moved to Cambridge University , where he accepted a Readership in Biochemistry at Trinity College and taught there until 1932.   During his nine years at Cambridge, Haldane worked on enzymes and genetics, particularly the mathematical side of genetics.   During the teens and twenties, Haldane wrote many popular essays on science that were eventually collected and published in 1927 in a volume entitled Possible Worlds.

JBS Haldane then accepted a position as Professor of Genetics and moved to University College London where he spent most of his academic career.   Four years later he became the first Weldon Professor of Biometry at University College London.   In the late 1950s he moved to India at the invitation of P.C. Mahalanobis .   The move was ostensibly a protest against the Suez War , but had been a possibility for some while; he was in any case facing retirement from UCL.   He became an Indian citizen.

In 1923 in a talk given in Cambridge, JBS Haldane, foreseeing the exhaustion of coal for power generation in Britain, proposed a network of hydrogen-generating windmills.   This is the first proposal of the hydrogen-based renewable energy economy [citation needed ] .

In 1924 Haldane met Charlotte Burghes (nee Franken) , a young reporter for the Daily Express, and the two later married.   To do so Charlotte divorced her husband Jack Burghes, causing some controversy.   Haldane was almost dismissed from Cambridge for the way he handled his meeting with her, which led to the divorce.

In 1925, GE Briggs and JBS Haldane derived a new interpretation of the enzyme kinetics law described by Victor Henri in 1903, different from the 1913 Michaelis-Menten equation .   Leonor Michaelis and Maud Menten assumed that enzyme (catalyst) and substrate (reactant) are in fast equilibrium with their complex, which then dissociates to yield product and free enzyme.   The Briggs-Haldane equation was of the same algebraic form, but their derivation is based on the quasi steady state approximation, that is the concentration(s) of intermediate complex(es) do(es) not change.   As a result, the microscopic meaning of the "Michaelis Constant" (km) is different.   Although commonly referring it as Michaelis-Menten kinetics , most of the current models actually use the Briggs-Haldane derivation.

JBS Haldane made many contributions to human genetics and was one of the three major figures to develop the mathematical theory of population genetics .   He is usually regarded as the third of these in importance, after R. A. Fisher and Sewall Wright .   His greatest contribution was in a series of ten papers on "A Mathematical Theory of Natural and Artificial Selection " which was the major series of papers on the mathematical theory of natural selection .   It treated many major cases for the first time, showing the direction and rates of changes of gene frequencies .   It also pioneered in investigating the interaction of natural selection with mutation and with migration.   JBS Haldane's book, The Causes of Evolution (1932), summarized these results, especially in its extensive appendix.   This body of work was a component of what came to be known as the "modern evolutionary synthesis ", reestablishing natural selection as the premier mechanism of evolution by explaining it in terms of the mathematical consequences of Mendelian genetics .

JBS Haldane introduced many quantitative approaches in biology such as in his essay On Being the Right Size .   His contributions to theoretical population genetics and statistical human genetics included the first methods using maximum likelihood for estimation of human linkage maps , and pioneering methods for estimating human mutation rates.   His was the first to calculate the mutational load caused by recurring mutations at a gene locus, and to introduce the idea of a "cost of natural selection".

JBS Haldane was a keen experimenter, willing to expose himself to danger to obtain data.   One experiment involving elevated levels of oxygen saturation triggered a fit which resulted in him suffering crushed vertebrae.   In his decompression chamber experiments, he and his volunteers suffered perforated eardrums, but, as Haldane stated in What is Life, "the drum generally heals up; and if a hole remains in it, although one is somewhat deaf, one can blow tobacco smoke out of the ear in question, which is a social accomplishment."

He was also a famous science populariser like Isaac Asimov , Stephen Jay Gould , or Richard Dawkins .   His essay, 'Daedalus; or, Science and the Future ' (1923), was remarkable in predicting many scientific advances but has been criticized for presenting a too idealistic view of scientific progress.

JBS Haldane was very idealistic, and in his youth was a devoted Communist and author of many articles in The Daily Worker and was the chairman of the editorial board of the London edition for several years.   In 1937, Haldane had become a Marxist, and an open supporter of the Communist Party, but not yet a member of the Party.   He would join the Party in 1942.   Events in the Soviet Union, such as the rise of the anti-Mendelian agronomist Trofim Lysenko and the crimes of Stalin, may have caused him to break with the Communist Party later in life, although known records show his partial support of Lysenko and Stalin rather than criticism or condemnation.  [1] He left the Communist party in 1950, shortly after having toyed with standing for Parliament as a Communist Party candidate.   However, his support for the Socialist ideal appears to be a pragmatic one.   Writing in 1928, in On Being the Right Size , JBS Haldane doubts whether the Socialist principle could be operated on the scale of the British Empire or the United States (or, implicitly, the Soviet Union): "while nationalization of certain industries is an obvious possibility in the largest of states, I find it no easier to picture a completely socialized British Empire or United States than an elephant turning somersaults or a hippopotamus jumping a hedge."   As late as 1962, he would describe Joseph Stalin as "a very great man who did a very good job".

He is also known for an observation from his essay, On Being the Right Size, which Jane Jacobs and others have since referred to as Haldane's principle.   This is that sheer size very often defines what bodily equipment an animal must have: "Insects, being so small, do not have oxygen-carrying bloodstreams.   What little oxygen their cells require can be absorbed by simple diffusion of air through their bodies.   But being larger means an animal must take on complicated oxygen pumping and distributing systems to reach all the cells."   The conceptual metaphor to animal body complexity has been of use in energy economics and secession ideas.

JBS Haldane was a friend of the author Aldous Huxley , and was the basis for the biologist Shearwater in Huxley's novel Antic Hay . I  deas from Haldane's Daedalus, such as ectogenesis (the development of fetuses in artificial wombs), also influenced Huxley's Brave New World .

The most famous of JBS Haldane's many students, John Maynard Smith , shared his mixture of political and scientific interests to some extent, but broke away from the Communist Party in 1956.

In 1952, JBS received the Darwin Medal from the Royal Society.   In 1956, he was awarded the Huxley Memorial Medal of the Royal Anthropological Institute.   Among other awards, he received the Feltrinelli Prize, an Honorary Doctorate of Science, an Honorary Fellowship at New College, and the Kimber Award of the U.S. National Academy of Sciences.

JBS Haldane died on December 1 , 1964 .   He willed that his body be used for study at the Rangaraya Medical College, Kakinada.  [2]“My body has been used for both purposes during my lifetime and after my death, whether I continue to exist or not, I shall have no further use for it, and desire that it shall be used by others.   Its refrigeration, if this is possible, should be a first charge on my estate...".

Some of JBS Haldane's works are:

      ...On Being the Right Size







Learn about Jack (JBS)'s Father, [ John Scott Haldane ], who invented the gas mask.




Learn about Jack (JBS)'s sister, [ Naomi Margaret Haldane ], a prolific writer,
who proof-read her friend's epic novel, Lord of the Rings.




Learn about Jack (JBS)'s Great GrandFather,
[ James Alexander Haldane ], who was an Evangalical Preacher.




Learn about [ Margaret Haldane, ]
my Great, Great, Great-Grandmother.



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